It's hard to tell without looking at a project file. Can you share the project, or tell us what type of cloud layer is having the problem? For example, if the cloud layer is a "Cloud layer v2" or "Cloud layer v3" this could be coming from the Density Fractal node assigned to cloud layer's Density shader. Under the Density Fractal node's Warping tab try reducing the Lead-in Warp Amount. The default value is 0.5 and when it's higher it tends to warp the fractal pattern towards a "swirling" shapes.
If you've disabled motion blur, it's definitely not a motion blur issue.