If you want to exclude cloud cache problems you might consider disabling it entirely, since it often causes problems like pixelated results for example.
You might even try to disable clouds entirely and then see if it still occurs. But disabling the cache would be the first thing to try, for me then.
It's hard to say what's best to use for ray detail region. Since you also see popping in the middle of the frame, and not only on the sides, I wonder if it will really help.
However, it never hurts
I guess you already know that a setting of 1 corresponds to 1 frustum outside the camera-frustum to be calculated.
So for a 500x500 image a ray detail region of 1 corresponds internally to a 1500x1500 image (3x500 horizontally and 3x500 vertically, with the camera-frustum in the middle).
I presume you also have detail blending enabled and set to 1?
Do you use small scale displacements? I'd go for as low octaves as possible.