There is a subtle difference but I've tried three times now to explain it and deleted each post because I couldn't get it.
You best solution is to try it out for your self.
Do a series of small renders (320x 240) and change only the coverage adjust in the cloud layer by 0.1 at a time.
Now do the same again leaving the cloud layer untouched but changing the coverage adjust in the density fractal also by 0.1.
You should see within an hour or so how the two differ.
Hetzen is of course right, you don't have to use a density fractal (cloud fractal shader), you can use normal power fractals, image maps, function networks or combinations.
Good luck and if you can find a nice concise way of describing it I'd like to see it
Cheers
Richard