Very interesting article. I read it all. Here are some thoughts:
1. If anything, I would say that physically we are evolving - people are growing taller, in many cases more athletic (compare 30 - 40 something's height with our grandmas). Many also enjoy excellent health and not because pharmacy but because nature constructed them this way. It is relatively uncommon to hear about mid-30 person suffering from a serious ailment or disease.
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2. Psychologically we are devolving. People are no longer able to express their thoughts in a free and coherent manner or have a model, healthy conversations with one another. Smartphones, Internet and apps have all the answers and set us free from thinking, taking decisions or engaging in a generally challenging (but more rewarding) social, face-to-face interactions.
Speaking from an anatomical point of view - a muscle or an organ that your body does not use is gradually disappearing. Brain is no exception. Mankind is a lazy species that likes to make life easier for themselves through little technological tidbits. However, I believe there is a certain threshold beyond which we become sitting ducks. And we are closer than farther from it these days...
In a very preliminary way, I see future humans as well-developed physically but with weak minds, used to comfort and freedom from thought.
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3. In regards to the previous point, do take a note that Darwin's theory itself has evolved. Survival of the fittest - how many people died in car wrecks due to them texting while driving or trying to enter GPS coordinates? Rejecting some of the life's "amenities" looks like a prudent, self-preservation strategy these days...
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4. Living for 250 years is not a problem. Living for 250 years and enjoying good health is! Wealth, experience and large, happy family nets you nothing if you are bound to a hospital bed for seventy years...
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5. Mind uploading and fusion with IT or machines have been mentioned time and again but, in my humble opinion, it may have horrific consequences.
Let's say that I just uploaded my mind into IT environment. Given the complexity of human brain, thoughts and consciousness, what guarantee do I have that I will sense and actually enjoy sunlight, talking to people, exercising and sleeping (some digital version of it anyway) the way I do now?
Consider this as well - digital data may or may not be accurate and some bits may go missing or simply become corrupted. What happens to my digital personality then? Will I become a digitaly-disabled person, because someone did not take proper care to preserve who I am? I will be trapped in a digital form as a messed-up computer code, until someone releases "Patch 1.03 for Andrzej"?
Even worse, what if my uploaded mind becomes infected with spyware or adware, effectively making me a zombie? And then someone erases my life with an antivirus as a "potential threat" or a "trojan"...?? Digitalizing human existence is hardly an "evolution" once you take these possibilities into account.