If you render with detail 0.5 @ 4k resolution you'll get lots more polygons rendered than when rendering with detail 0.5 @ 1k resolution.
So from that point of view the result will be better, simply because of the resolution.
At such big resolutions I think I wouldn't go beyond render detail 0.6-0.7. Otherwise it just takes too long.
If you use vegetation, use AA4 with maximum samples or AA6 with max samples if you can afford the rendertime.
If you do not use vegetation, then use AA3 or 4 with standard sampling.
GI should be good enough @ GI rel. detail 1, sampling quality 2-3 and blur radius 8.
Depending on the lighting I would not use more than 32 atmo samples. I think I would start at default 16 or 24.
Cloud samples tells us nothing without knowing the detail level it results in.
128 cloud samples can be detail 3 or detail 0.3, depening on cloud depth and density.
At such big resolutions see if a detail level of 0.5 gives you satisfactory results.
If the noise is too high increase with 0.1 increments.
For both atmosphere and clouds you can use ray traced atmosphere.
It gives better results with less samples, but also takes longer as I've recently shown:
http://forums.planetside.co.uk/index.php?topic=13679.15If you don't need transparency in the water or simply just can't see it: disable it as it will chop of quite some rendertime.