For large resolution you can often reduce sampling a bit in general.
Because you increase the resolution you also increase the space you're sampling in.
This means that if you double your resolution you will "collect" 4x more samples if you don't touch the settings.
So often you can tune them a bit down because the higher resolution itself already provides more detail and can potentially reduce strong contrasts which requires more sampling.
It's a bit difficult to explain, but I hope you understand.
Richard (Cyphyr) recently performed a huge render with drastically reduced settings which gave an almost exact same outcome as the small version with much higher sampling for atmosphere and GI, for example.
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