I too have a 4GIG on hand, but now have a 16GIG also.
I thought of a couple of things that might help.
Just before you are ready to push Render Sequence, in the preview window, hide your objects. Then put your viewport to Terrain. Make sure RTPreview is off also. All of these features really slowed down my unit on a complex scene. If you have a lot of populations, see if using pop cache helps.
I am just giving some hints that may or may not have a thing to do with your problem, but my unit handled TG better doing those things.